Liana Mosca, whose parents are Italian and American, was born in Zurich and began studying the violin with Lee Robert Mosca at the Suzuki Talent Center in Turin. In 1988 she received her music degree at the Milan Conservatory under Osvaldo Scilla. In 1993 she obtained her Konzert-Diplome at the Musik Akademie der Stadt Basel under Heinzhein Schneeberger. In 1987 she won the first of many competitions in Italy, and joined the Gustav Mahler Jugendorchester and the Youth Orchestra of United Europe, directed by Claudio Abbado. In 1993 she became a member of the Deutche Kammerakademie directed by Johannes Goritzky, and in 1998 she began performing with the early music ensemble Il Giardino Armonico, directed by Giovanni Antonini, which she continues to do to this day. In 2001 she was granted a Kammermusik diploma at the Vienna Conservatory, as a student of the Altenberg Trio. Liana Mosca also takes parts in various projects with the Swiss Baroque Soloists, Academia Montis Regalis, Accademia del Santo Spirito, Ensemble Baroque de Limoges and, as first violin, in the Como's Theatre Orchestra 1813, Milano Classica, Accademia dei Solinghi and Musici Estensi. Since 2010 she has been a member of the newly-founded Ensemble Cappella Gabetta and the Ensemble Claudiana, directed by Luca Pianca wich whom she is taking part in the performance of all the Cantatas by J.S. Bach, in the Wienerkonzerthaus. She is also involved in research into the evolution of the Sonata for fortepiano and violin from 1750 to 1810, conceived by the musicologist Hervé Audéon, with Pierre Goy and Nicole Hostettler, as part of the training courses at the Fondation Royaumont.

She recorded for many labels such as Decca, Naïve, Lyrinx. Among others the Pugnani Sonate and Triosonate for the label Stradivarius, music by Chopin with the Ensemble 1813 on period instruments, and works by Bohely, Albrechtsberger and Haydn with the Ensemble Baroque de Limoges on the viola and viola d’amore .

She teaches at the Accademia Suzuki in Turin and is a Teacher Trainer with the Suzuki Institute.